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Katarzyna Kieć-Kononowicz Selected Research

Histamine H3 Receptors (Histamine H3 Receptor)

6/2022KSK-74: Dual Histamine H3 and Sigma-2 Receptor Ligand with Anti-Obesity Potential.
10/2021Histamine H3 Receptor Ligands-KSK-59 and KSK-73-Reduce Body Weight Gain in a Rat Model of Excessive Eating.
10/2021Metabolic benefits of novel histamine H3 receptor ligands in the model of excessive eating: The importance of intrinsic activity and pharmacokinetic properties.
1/2021Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease.
1/2021Ameliorating effects of histamine H3 receptor antagonist E177 on acute pentylenetetrazole-induced memory impairments in rats.
12/2020Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer's disease.
11/2020N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins.
11/2020Corrigendum to "Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands" [Eur. J. Med. Chem. 185 (2020) 111785].
6/2020The Dual-Active Histamine H3 Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice.
3/2020Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats.
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Katarzyna Kieć-Kononowicz Research Topics

Disease

10Alzheimer Disease (Alzheimer's Disease)
01/2021 - 12/2013
10Epilepsy (Aura)
01/2021 - 09/2013
8Obesity
06/2022 - 10/2016
7Body Weight (Weight, Body)
10/2021 - 01/2018
6Inflammation (Inflammations)
03/2021 - 01/2015
6Seizures (Absence Seizure)
10/2018 - 09/2011
5Pain (Aches)
01/2022 - 01/2013
5Memory Disorders (Memory Loss)
06/2021 - 01/2017
5Neurodegenerative Diseases (Neurodegenerative Disease)
06/2021 - 01/2008
5Cognitive Dysfunction
03/2020 - 01/2018
4Edema (Dropsy)
03/2021 - 08/2014
4Asthma (Bronchial Asthma)
01/2021 - 01/2013
4Neoplasms (Cancer)
01/2021 - 01/2016
4Neuralgia (Stump Neuralgia)
12/2020 - 10/2017
4Autistic Disorder (Autism)
06/2020 - 01/2018
3Weight Gain
06/2022 - 01/2018
3Pruritus (Itching)
01/2021 - 01/2013
3Lymphoma (Lymphomas)
01/2021 - 01/2016
3Parkinson Disease (Parkinson's Disease)
05/2020 - 01/2008
3Neuroblastoma
05/2020 - 01/2014
2Colitis
01/2021 - 01/2021
2Central Nervous System Diseases (CNS Diseases)
01/2021 - 12/2019
2Amnesia (Dissociative Amnesia)
12/2020 - 01/2019
2Catalepsy
05/2020 - 01/2015
2Schizophrenia (Dementia Praecox)
01/2020 - 10/2019
2Narcolepsy
01/2020 - 10/2019
2Leukemia
11/2017 - 01/2016
2Hypersensitivity (Allergy)
01/2015 - 01/2013
2Cardiac Arrhythmias (Arrythmia)
04/2012 - 12/2004
1Hypertrophy
06/2022
1Nausea
10/2021
1Nervous System Diseases (Neurological Disorders)
04/2021
1Atopic Dermatitis (Atopic Eczema)
01/2021
1Allergic Rhinitis
01/2021

Drug/Important Bio-Agent (IBA)

24LigandsIBA
06/2022 - 01/2013
21Histamine H3 Receptors (Histamine H3 Receptor)IBA
06/2022 - 09/2013
11Histamine (Histamine Dihydrochloride)FDA Link
06/2022 - 09/2010
6Histamine H4 ReceptorsIBA
01/2021 - 01/2015
5Glucose (Dextrose)FDA LinkGeneric
06/2022 - 01/2018
5CarrageenanIBA
03/2021 - 08/2014
5Dizocilpine Maleate (Dizocilpine)IBA
12/2020 - 01/2017
5Anticonvulsants (Antiepileptic Drugs)IBA
03/2020 - 09/2011
5Pharmaceutical PreparationsIBA
12/2019 - 09/2006
5Phenytoin (Dilantin)FDA LinkGeneric
11/2017 - 09/2013
4Analgesics (Analgesic Drugs)IBA
12/2020 - 01/2017
4EsterasesIBA
06/2020 - 10/2019
4Acetylcholine (Acetylcholine Chloride)FDA Link
06/2020 - 10/2019
4Pentylenetetrazole (Metrazol)IBA
03/2020 - 07/2015
4Neurotransmitter Agents (Neurotransmitter)IBA
03/2020 - 01/2018
4pitolisantIBA
01/2020 - 06/2014
3Scopolamine (Hyoscine)FDA Link
06/2021 - 01/2017
3Monoamine Oxidase (MAO)IBA
06/2021 - 01/2020
3Purinergic P1 Receptors (Adenosine Receptor)IBA
03/2021 - 12/2013
3Valproic Acid (Depakote)FDA LinkGeneric
06/2020 - 01/2018
3Neuroprotective AgentsIBA
05/2020 - 11/2019
3HydantoinsIBA
12/2019 - 01/2016
3Formaldehyde (Formol)FDA Link
01/2019 - 10/2017
3imidazoleIBA
01/2019 - 09/2013
2Triglycerides (Triacylglycerol)IBA
06/2022 - 10/2016
2EnzymesIBA
06/2021 - 01/2020
2ZymosanIBA
03/2021 - 01/2017
2Interleukin-6 (Interleukin 6)IBA
03/2021 - 01/2021
2Member 1 Subfamily B ATP Binding Cassette TransporterIBA
01/2021 - 01/2016
2Haloperidol (Haldol)FDA LinkGeneric
05/2020 - 01/2015
2Dopamine (Intropin)FDA LinkGeneric
01/2020 - 01/2015
2Serotonin ReceptorsIBA
12/2019 - 07/2019
2Ethanol (Ethyl Alcohol)IBA
01/2019 - 11/2015
2Donepezil (Aricept)FDA LinkGeneric
01/2018 - 01/2017
2Cytochrome P-450 CYP3AIBA
01/2018 - 08/2014
2barium chloride (barium dichloride)IBA
04/2012 - 12/2004
2Epinephrine (Adrenaline)FDA LinkGeneric
04/2012 - 12/2004
1ResistinIBA
06/2022
1sigma-2 receptorIBA
06/2022
1LeptinIBA
06/2022
1KaolinIBA
10/2021
1ClayIBA
10/2021
1Histamine H3 AntagonistsIBA
10/2021
1ButyrylcholinesteraseIBA
06/2021
1diphenyl (biphenyl)IBA
06/2021
1CytokinesIBA
03/2021
1psb-603IBA
03/2021
1Adenosine A2B ReceptorIBA
03/2021
1Adenosine (Adenocard)FDA LinkGeneric
03/2021
1Adenosine A2 Receptor AntagonistsIBA
03/2021
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2021
1Peroxidase (Myeloperoxidase)IBA
01/2021
1AcidsIBA
01/2021
1AminesIBA
01/2021
1Biological ProductsIBA
01/2021
1Verapamil (Calan)FDA LinkGeneric
01/2021
1Cholinesterases (Cholinesterase)IBA
01/2021
1imidazolidine-2,4-dioneIBA
01/2021
1Proteins (Proteins, Gene)FDA Link
11/2020
1PiperazineIBA
11/2020
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
05/2020
1Glutathione (Reduced Glutathione)IBA
03/2020
1gamma-Aminobutyric Acid (GABA)IBA
03/2020
1Superoxide DismutaseIBA
03/2020
1Glutamic Acid (Glutamate)FDA Link
03/2020

Therapy/Procedure

5Therapeutics
01/2022 - 01/2018